Introduction Innovation

LIMIS combines specific medical knowledge with business and marketing concepts for innovative new technologies, products and concepts. For all projects, LIMIS cooperates with several specialized companies, hospitals and healthcare institutions, knowledge institutions and universities.


Anastomotic leakage (AL) is a major complication worldwide with occurrence rates ranging up to 13% and a mortality of around 10%. AL occurs after a colon resection roughly 4 days post-surgery and requires re-operation a prolonged hospitalization. AL is multi-factorial meaning that it is hard to determine the exact cause, however general consensus is that the state of perfusion at the site of the anastomosis is a major contributor. Currently surgeons determine the state of microcirculation based on subjective measures of viability such as tissue colour and palpable motion or bleeding at the resected edges. Lapvas is the development of a laparoscopic tool that can visualize the state of microcirculation at any given time during laparoscopic surgery.

Reducing anastomotic leakage during intestinal surgery

Laparoscopische chirurgieWithin the 'anastomotic leakage' project we examine a measuring instrument that shows the quality of tissue of the intestinal wall. This provides an improved decision parameter for the operating surgeon. This concerns a minimally invasive application. In this project we work together with the UMCG, prof. dr. Gooitzen M. van Dam.

Anastomotic leakage after an intestinal operation is a global problem. If the number of anastomotic leakages is reduced, this means fewer days of intensive care, fewer reoperations and the improved recovery of patients. In cooperation with the UMCG we examine the effect of the oxygen content in the tissue in relation to anastomotic leakage.

Virtual Operation Room as training tool (past project)

Virtual Operating RoomThe virtual operating room (OR) is an on-line training tool for OR assistants. This is a LIMIS innovation and is developed in cooperation with Grendel Games. OR assistants learn how to handle complicated OR equipment and simulate realistic situations. This contributes to a safe and efficient OR environment.

The virtual OR is a fully equipped virtual operating room in which you can walk to the equipment and operate it with your mouse or controller. The virtual instruments have all the possibilities that the real equipment also has. In the virtual room you can simulate realistic problems and learn how you can resolve them. It is a good way to playfully train in the use of operating techniques.

ICT plays an important role in improving the efficiency and effectiveness of training programmes. This provides many benefits. The surgeon does not practice on a patient and can therefore cause no damage. The operation can be repeated as often as is necessary. The program keeps score and shows who has already performed a specific training. In addition, the virtual room also provides information about the layout of the operating room and the ergonomics. The virtual operating room is developed in cooperation with Grendel Games and Olympus Europe. A number of scenarios have been completed.

Lap Wii Trainer (past project)

Lap Wii TrainingstoolThe Nintendo Wii U Laparoscopy Trainer is a training game for laparoscopic skills on a standard Nintendo Wii U as replacement for an expensive simulator. This innovation is developed by Cutting Edge, a collaboration between UMCG, Grendel Games and LIMIS. An inexpensive, innovative and sustainable solution has been developed for training the skills necessary for exploratory surgery. Research has shown that simulators are often boring, ineffective and expensive. Due to their highly technical nature simulators are susceptible to defects and generate high maintenance costs. This has led to the collaboration and a challenging, accessible and validated solution has been developed together with game developers. The development of the hardware has been handled in partnership with Pezy Product Innovation. The product 'Underground' had been launched in Q4 2015 and is available in the Nintendo web-shop.

E-coaching excess weight program - BlijvendinBalans (past project)

Excess weight and obesity form a major threat for public health: excess weight leads irrevocably to health complaints. LIMIS has taken the initiative to apply the options offered by e-Health to improve the health of people suffering from excess weight and obesity. With this on-line solution we can help large groups of people at relatively low cost.

The program focuses on a permanent change of behaviour. It is based on scientific insights and a lot of knowledge from the MCL and the LIMIS organization itself. Participants receive personal advice. Furthermore the program offers interaction with other participants.

Training on the OR of the Future (past project)

This innovation is focused on the publication of visual material for surgical procedure training (minimally invasive) on the basis of a subscription structure. This is a continuation of the INVEST PhD research of Dr. Marc van Det, surgeon. The general trainings can be used in training institutes for surgeons and operating assistants. In addition, complex sub-procedures of operations will be filmed for experienced surgeons. This innovation also offers possibilities for the medical industry to provide specific instructions during training in the use of new endoscopic equipment. LIMIS works together with surgeons, local ICT companies and image processing companies.

The LIMIS project Lapvas-Imaging is jointly financed by SNN and the European Regional Development Fund and the Ministry of Economic Affairs, Agriculture and Innovation. With this project we invest in your future.